The primary role of Mouse Genetics Core Facility (MGCF) is to facilitate the use of mouse molecular genetics at MSK for in vivo studies of gene functions germane to cancer. Relevant fields in which ...

After 5-10 generations of inbreeding, mouse colonies should be “refreshed”, to remove or prevent genetic drift accumulation in the colony. Several methods to refresh the genetic background may include ...

The laboratory mouse has been widely used for research on a variety of diseases and genetic studies to understand which genes are involved in various illnesses. However, actual variations in past ...

There is general appreciation that 'genetic background effects' can profoundly affect the immune phenotypes of congenic, transgenic and knockout mice. We suggest that attributing phenotypes to genetic ...

Scientists from the Jackson Laboratory (JAX) have described how they combined stem cells from eight different mouse strains to create a model for studying neurological conditions that better mimics ...