MD Anderson studies reveal how cancer cells rewire metabolism to spread. A glucose–fructose mix promotes colorectal metastasis via cholesterol pathways, while fatty-acid oxidation driven by ACBP ...

Phosphatidate phosphatase (PAP) enzymes play a pivotal role in lipid metabolism, acting as a control point that directs metabolic flux between membrane phospholipid synthesis and the production of ...

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC). This ...

Faulty lipid regulation in CLL patients impairs T-cell function, affecting treatment outcomes and resistance to current therapies. Differences in lipid metabolism between CLL patients and healthy ...

The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into ...

A compound from ginger stops cancer cells from making fats and drains their energy, exposing a metabolic weakness in cancer cells.

"One reason managing blood sugars can lower your cholesterol is through improved insulin sensitivity, which directly ...

Moreover, the researchers discovered that targeting the dysregulated lipid pathways in Schwann cells could potentially reverse some of the detrimental effects of the PMP22 duplication. By modulating ...