The attachment of sister kinetochores to microtubules from opposite spindle poles is necessary for accurate chromosome segregation during cell division. Unattached kinetochores activate the cell-cycle ...

Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

In human cells, lengthy strands of DNA have to be carefully organized and compacted so they'll fit into the nucleus; our genome is arranged into chromosomes that have to be duplicated each time a cell ...

The kinetochore can be thought of as three sets of subcomponents: (a) The chromosomal DNA-inner kinetochore protein interface (further details of this interface are shown in Figure 4), (b) the inner ...

During mitosis, replicated chromosomes are separated to daughter cells by the microtubule-based mitotic spindle. Chromosomes attach to the mitotic spindle through specialized DNA/protein structures ...

(Phys.org) -- With the first-ever three-dimensional image of an isolated kinetochore – the bulky molecular machine that connects a chromosome to the long, thin microtubules that tug it to one end of a ...

The kinetochore connects chromosomes to spindle microtubules, corrects attachment errors, and triggers the separation of sister chromatids. It is built from more than 100 proteins, grouped into around ...

In living organisms cells divide and reproduce in two ways, mitosis and meiosis. Mitosis results in two identical daughter cells, whereas meiosis results in four sex cells. During mitotic and meiotic ...

This is a preview. Log in through your library . Abstract Identification of proteins that couple kinetochores to spindle microtubules is critical for understanding how accurate chromosome segregation ...

The cell cycle, the biological process underlying how cells grow and multiply, is tightly regulated to ensure a faithful distribution of genetic material to ‘daughter’ cells. This tight regulation of ...

Crowning a quest into a very well-guarded secret: Structure of the kinetochore corona finally revealed Date: April 8, 2022 Source: Max Planck Institute of Molecular Physiology Summary: During cell ...