While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

The gastrointestinal (GI) epithelium is the body’s first line of defense to luminal contents such as food, microbiota, pharmaceuticals, and toxins. A small pool of proliferative stem and progenitor ...

Inflammatory bowel disease (IBD) is a major global health concern, with an estimated 1.6 million cases in the US alone. While there are many treatments available, they are often ineffective and can ...

Infectious microbes have evolved sophisticated means to invade host cells, outwit the body's defenses and cause disease. While researchers have tried to puzzle out the complicated interactions between ...

In vivo, the intestinal epithelium interacts with the neighboring environment through complex crosstalk, which involves components such as the immune system, tissue microenvironment, and gut microbes.

Stem cells are a hot topic for creating medical treatments. However, scientists still do not fully understand how they choose to divide or differentiate to renew organs. Researchers have now found a ...

A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular ...