Antibody humanization and affinity maturation have revolutionized the biotech industry in the past 10–20 years, enabling the development of highly effective therapeutic antibodies that can be used to ...

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Back mutations, restoring critical non-human residues to retain binding affinity. Computational modeling and in silico tools to predict stability, reduce immunogenic epitopes, and optimize sequences.

Integral Molecular Uses Shotgun Mutagenesis to Germline-Humanize Monoclonal Antibodies Seventy percent of FDA-approved monoclonal antibodies (mAbs) and approximately 66% of mAbs currently in clinical ...

The "Antibody Humanization and Affinity Maturation: Services and Platforms, 2017-2030" report has been added to Research and Markets' offering. The "Antibody Humanization and Affinity Maturation: ...

In the context of Immunex’s patent on IL-4 antibodies, the Federal Circuit says yes. On October 13, 2020, the Federal Circuit affirmed the Patent Trial and Appeal Board’s (the “Board”) final written ...

An international research consortium, led by scientists at VIB and UGent, has developed a new platform that could change how ...

Antibody engineering and production are essential tools in drug discovery, providing powerful and specific therapeutics and diagnostic/prognostic materials for various diseases. Antibodies are ...

Antibodies play a vital role in the immune system by providing protection against foreign invaders, such as bacteria and viruses. Produced by B cells, antibodies are protein molecules that can be ...